One of the most common alterations was copy number gains at locus 8q24, which concerned 27 (13.5%) CBF-AML patients through several mechanisms (Supplementary Figure 7): 14 (7%) patients had +8, 4 (2%) patients had broad gains of the long arm of the chromosome 8 and the 9 (4.5%) remaining patients harbored focal gains that contained a single putative gene referred to as CCDC26 which has been recently linked to myeloid leukemia cell growth [18]. Here, CCDC26 is linked to myeloid leukemia.