While the MDR defined by Kühn et al did not contain EZH2, by contrast with the present study, the high frequency of polycomb mutations (ASXL1, ASXL2 and EZH2) in t(8;21)-AML suggest that EZH2 haploinsufficiency could be of interested, at least in t(8;21)-AML patients [6, 27]. Here, ASXL1 is linked to acute myeloid leukemia.