EGFR and non-small cell lung carcinoma: EGFR has also been found to accumulate in the perinuclear space of cells in non-small cell lung cancer cells, but only under conditions in which EGFR has been mutated, allowing for increased interactions between EGFR and the cancer-associated protein Src [50], emphasizing the abnormality of extended EGFR retention in the perinuclear space.