When the MYCN amplified and non-MYCN amplified High-MKI cases were combined (n = 241), 161 tumors were prominent nucleolar formation (+) and 139 (86.3%) of them were MYC family-driven neuroblastomas with MYCN protein (+), MYC protein (+), or both (+), as shown in Figure 2B. The gene discussed is MYC; the disease is neuroblastoma.