When combining heparanase staining in the primary tumor and its metastases (42 pairs), the following results were obtained: In 26 cases there was no difference between heparanase staining in the primary tumor vs metastases (strong remained strong, weak or negative remained weak or negative), whereas in 16 cases (38%) heparanase expression was changed significantly (Table 1). This evidence concerns the gene HPSE and neoplasm.