High expression of the RNA-binding motif protein 3 (RBM3) has been demonstrated to be an independent prognostic and predictive biomarker in several types of solid tumors such as malignant melanoma, breast, ovarian, prostate, bladder, colorectal, esophageal, gastric, and non-seminomatous testicular cancer [7–15]. Here, RBM3 is linked to melanoma.