Thus, the markedly increased CpG island methylation (and decreased gene expression) of NFATc genes 1 and 2 (Figure 4 and Supplementary Table 2 in ref. [6]), that we have found in the primary breast cancer of our patient (but not in the metastatic LN), could result in a potent localized “cyclosporine-A like immunosuppressive effect” to the benefit of cancer cells in the primary cancer stroma but not in the metastatic LN. The gene discussed is NFATC1; the disease is breast cancer.