Given that C3 inhibits BrdU uptake, downregulates MCM family proteins, and downregulates c-myc activity, we propose that C3 is a bona fide anti-proliferative agent that warrants further pre-clinical investigation in the realm of prostate cancer drug discovery and development, and that 37 LR continues to be a promising avenue for targeted therapeutic intervention. This evidence concerns the gene MYC and Familial prostate cancer.