Because the functions of 37 LR and PEDF are diverse and the mechanisms underlying PEDF’s anti-tumor properties are still unclear (in contrast with its well-characterized role in anti-angiogenesis), we employed an unbiased label-free quantitative mass spectrometry approach to determine the types and levels of proteins modulated in PC-3 cells following treatment with a moderate dose of C3 (10 μM), chosen from the BrdU and t-scratch functional assays. The gene discussed is SERPINF1; the disease is neoplasm.