NF-κB activation induces a signaling pathway by accelerating the expression of several receptors, ligands and transcriptional factors that regulate NF-κB activation and immune response through NF-κB, while inhibition of NF-κB negatively affects the gene expression profiling of the NF-κB signaling pathway, and has been considered promising for improving anti-cancer therapies [27]. Here, NFKB1 is linked to cancer.