In this work we demonstrated that although RAC3 is a high expression molecule in human colorectal tumors, its levels could be modulated along the cancer progression together with cancer stem cell markers, being probably higher in states associated with initiation, major propagation invading secondary focus, and aggressiveness where an important amount of cancer stem cells are required, having the ability to migrate and invade new tissues in order to build the new metastatic focus. This evidence concerns the gene RAC3 and cancer.