MAP3K1 and Familial prostate cancer: For example, miR23B targets a mitochondrial tumor suppressor proline oxidase (POX) and over-expression of miR23B results in down-regulation of POX in renal cancer [36]; in prostate cancer miR23B leads to attenuated Sre expression and decrease in tumor growth in nude mice; miR23B also exhibited metastasis suppression effect in colon cancer and its targets include FZD7 or MAP3K1 [37].