In the AOM/DSS model, the PLCγ1, Bak, and cleaved PARP levels were significantly increased in tumors isolated from WT mice, whereas cleaved caspase-3 levels were decreased; however, in PLCγ1 conditional knockout mice, phospho-AKT, phospho-STAT3, and phospho-p65 were all decreased (Figure 2). Here, CASP3 is linked to infectious otitis media.