STAT3 and infectious otitis media: To investigate the effects of PLCγ1 on CAC tumorigenesis, particularly on the IL-6/STAT3 signaling pathway in AOM/DSS-treated mice, a deletion mutant of PLCγ1 was used in a tumorigenic model of CAC and was shown to prevent inflammation by inhibiting the phosphorylation of STAT3 on Tyr705 [48].