Although we have shown that the knockdown of PLCγ1 induces apoptosis in the AOM-DSS model by mechanisms involving the downregulation of the IL-6/STAT3 signaling pathway, we aimed to demonstrate that PLCγ1 may be an effective treatment for CRC by blocking the IL-6/STAT3 signaling. The gene discussed is PLCG1; the disease is colorectal carcinoma.