NRAS and melanoma: The mutations found in melanoma mostly involve the mitogen-activated protein kinase (MAPK) and the phosphoinositide 3-kinase/protein kinase B (PI3K/AKT) pathways, with BRAFV600E representing the most common mutation (about 60%) and mostly correlated with intermittent sun exposure [5, 6] followed by NRAS (28%) and NF1, encoding for the neurofibromin 1 protein (14%) [2, 7, 8].