For example, peripheral Aβ clearance via administration of Aβ binding protein gelsolin is therapeutically active in Tg2576 AD transgenic mice [5], but enhanced peripheral Aβ degradation via administration of neprilysin to APP23 mice and Tg2576 mice did not impact brain Aβ level [36, 37]. The gene discussed is MME; the disease is Alzheimer disease.