DDIT3 and acute lymphoblastic leukemia: As shown in Figure 1C, co-treatment with pevonedistat plus BAPTA-AM led to increased expression of CHOP compared to each agent alone, and correlated with greater induction of apoptosis in cells treated with both agents as demonstrated by increased PARP cleavage, suggesting that CHOP may also influence Ca2+ mobilization in pevonedistat-treated ALL cells.