Based on the established requirement for Ca2+ binding in the activation of PKCs [21] and the role of p-CaMKII in Ca2+ homeostasis [22], the observed increased cellular levels of p-CaMKII (Thr286) in all three ALL cell lines (Figure 1A) suggested that mobilization of Ca2+ may play a role in pevonedistat induced MEK/ERK activation. The gene discussed is MAP2K7; the disease is acute lymphoblastic leukemia.