To see if miR-17 suppression influenced the immune response or if the LNP led to any deleterious immunostimulatory effects, we measured T-cells (CD4+) and macrophages (F4/80) infiltration in anti-miR-17 versus control treated MYC-induced HCC and found no significant differences (Supplementary Figure 4). The gene discussed is MYC; the disease is hepatocellular carcinoma.