In this study, we found higher NEAT1 expression in the PBMCs of patients with sepsis than in healthy volunteers by qRT-PCR, although NEAT1 levels in the SIRS group are higher than those in the control group, but significantly lower than the set of sepsis, indicating that increased inflammation can lead to higher levels of NEAT1. According to previous studies, human umbilical vein endothelial cells (HUVECs) infected with hantavirus exhibit increased NEAT1–1 expression. The gene discussed is NEAT1; the disease is systemic inflammatory response syndrome.