We choose two human CTLA-4 mAbs for this study: the clinically used Ipilimumab and L3D10, the most potent among our panel of anti-CTLA-4 mAbs.24,28 When compared in the same model, the two mAbs were comparable in causing tumor rejection (Supplementary information, Figure S1). The gene discussed is CTLA4; the disease is neoplasm.