We formally tested this hypothesis with respect to the set of ten genes with strongest evidence for carrying causal variants in our whole-genome sequencing CAS analyses: CHD3, SETD1A, WDR5, KAT6A, SETBP1, ZFHX4, TNRC6B, MKL2, ARID1A and TRIO. These include the eight genes with a mutation that was classified as pathogenic or likely pathogenic, as well as the two genes that had a missense mutation and that were previously implicated in neurodevelopmental disorders. The gene discussed is SETBP1; the disease is neurodevelopmental disorder.