Similar analysis with genes associated with loci that showed hypomethylatation upon VHL expression in cell lines and hypermethylatation in ccRCC tumors returned only 3 genes whose expression showed negative correlation to the CpG methylation; HOXB8, FAM89A and PPP2R2D, of which none were among the HIF-target genes. The gene discussed is VHL; the disease is nonpapillary renal cell carcinoma.