EGF and autosomal dominant polycystic kidney disease: As shown in Fig. 6a and b, DAPT alone did not influence cyst formation or growth, however in combination with FSK and EGF (agonists), decreased the surface area of FSK/EGF-induced ADPKD cysts (p < 0.01), demonstrating that Notch inhibition suppresses cell proliferation and/or chloride-dependent fluid secretion.