For example, it has been demonstrated that GRK5 low expression is associated with TSH receptor-stimulated high level of cAMP in several human thyroid cancer types (DTC)33; TIG-1 inhibits colon cancer cell HCT116 proliferation by inducing GRK5 expression34; co-expression of GRK5 inhibits Kaposi’s sarcoma cell proliferation induced by constitutive activation of human herpesvirus -8 (KSHV) G protein-coupled receptor35. This evidence concerns the gene TSHR and thyroid cancer.