We found that the percentage of positive intensive GRK5 expression is significantly higher in NSCLC cancerous tissues (70.3%; 379/539) than that in normal lung tissues (45.5%; 45/99), also higher in ADC (75.3%; 219/291) and female (76.1%; 108/142) cancerous tissues than that in SCC (64.5%; 160/248) and male (68.3%; 271/397) cancerous tissues, respectively (Fig. 1d). The gene discussed is GRK5; the disease is non-small cell lung carcinoma.