In contrast to Y. pestis, infection with Salmonella enterica serotype Typhimurium, another intracellular pathogen, had no significant impact on TfR recycling (Fig. 6I and J) (S. enterica Typhimurium infection of macrophages was independently monitored to ensure bacterial infection, growth, and host cell viability [Fig. S3]). The gene discussed is TFRC; the disease is bacterial infectious disease.