This loop may be relevant in human tumors, because MYC and FGFR3 expression levels were found to be positively correlated in tumors bearing FGFR3 mutations in two independent transcriptomic datasets (n = 63 and n = 271), and because FGFR3 inhibition in a patient‐derived tumor xenograft (PDX) model harboring an FGFR3‐S249C mutation decreased the levels of both MYC and FGFR3. The gene discussed is FGFR3; the disease is neoplasm.