Hence, our study provides significant insights into the novel roles of HMGB2 as a promoting factor of breast cancer progress through regulating of proliferation and glycolysis.The Warburg effect, also known as aerobic glycolysis, is a shift from oxidative phosphorylation to glycolysis, and is considered to be a hallmark of cancer development and progression [26, 27]. The gene discussed is HMGB2; the disease is breast cancer.