Here, we feature the expression dynamics of MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MCM8, MCM9, MCM10 and RecQ like helicase 4 (RECQL4) in the typical multistep of hepatocarcinogenesis and demonstrate the association between MCMs and clinicopathological characteristics, diagnosis and prognosis in HCC patients. The gene discussed is RECQL4; the disease is hepatocellular carcinoma.