Production of 30 cytokines, chemokines, and growth factors by the ZIKV-infected astrocytes was measured in culture media at 1, 2, and 4 days p.i. The analysis showed that the infection was associated with limited immune cytokine/chemokine response activation; the highest increase of expression, following infection, was seen in CXCL-10 (IP-10), interleukin (IL)-6, 8, 12, and CCL5 (RANTES). This evidence concerns the gene CCL5 and infection.