CISH and in situ carcinoma: Table 2 further reveals that values of the AUC0–72 for CIS by SC administration of 2DTX1/CIS1 and P13L0.15O1.52D1C1 were 19,090.21 ± 1003.34 and 18,396.05 ± 3127.88 ng/h/mL, respectively. The Cmax for CIS by SC administration of P13L0.15O1.52D1C1 was 531.64 ± 91.11 ng/mL, which was an ∼1.06-fold decrease compared to that for 2DTX1/CIS1 at 561.59 ± 45.50 ng/mL. The results suggest that SC administration of PLO gels containing the synergistic combination of DTX and CIS was able to delay the absorption of CIS into the systemic circulation, resulting in lower Cmax and AUC values.