Knockdown of GS inhibits SK-BR-3 proliferation (a human epidermal growth factor receptor 2-enriched breast cancer cell line) and abrogates p38 mitogen-activated protein kinase (MAPK) and extracellular signal-regulated kinase 1/2 (ERK1/2) signaling pathways [79]. This evidence concerns the gene MAPK3 and breast carcinoma.