In skeletal muscle PGC-1α regulates the molecular and biochemical events that underlie muscle remodeling in response to physical exercise, by inducing mitochondrial biogenesis, slow fiber conversion, stimulation of fatty acid oxidation and angiogenesis, increased levels of PGC-1α have a protective role against atrophy, obesity, and diabetes [209,210,211]. Here, PPARGC1A is linked to diabetes mellitus.