Because frondoside A has similar growth inhibitory effects in cancer cells regardless of their p53 status, a study was conducted to investigate the effects of frondoside A and cisplatin after pretreating cells with pifithrin-α (Pif-α), which is a chemical inhibitor of p53 transcriptional activity in wild-type p53 BL-2 Burkitt lymphoma cells [20]. This evidence concerns the gene TP53 and cancer.