However, this study showed that the reintroduction of WRN protein in AG11395 cells did not inhibit recombination but facilitates the transition to a different recombination mechanism very similar to ALT mechanisms observed in human cancer cells and resembles the one used by yeast type II survivors (in which the amplification of the telomeric TG1-3 regions occurs through a recombination-dependent mechanism involving the yeast RecQ helicase Sgs1). This evidence concerns the gene GPT and cancer.