GPT and neoplasm: In this way, we can hypothesize about the possibility of a “repression-loss” even in patients in vivo, that (in conjunction with the repression of the preexisting TMM) can result in tumors that display different subpopulations of telomerase- and ALT-positive cell lines, if these modifications concern about few cells (Figure 1a); or tumors that display coexistence of the two TMMs within the same cells, if the “repression-loss” concern the whole tumor in an early stage of development (Figure 1b).