Haxho et al. found that GPCR agonists bombesin, bradykinin (BK), angiotensin I, and angiotensin II each significantly and dose-dependently induced Neu-1 sialidase activity and IR activation in human IR-expressing rat hepatoma cell lines (HTC-IR) in the absence of insulin [8]. The gene discussed is AGT; the disease is hepatocellular carcinoma.