Recently, Sancho-Martinez et al. [70], by inducing a genetic manipulation of p53 and receptor tyrosine kinase signaling in NSCs obtained by human-induced pluripotent stem cells, demonstrated the acquisition of CSC-like features in vitro, including enhanced self-renewal and migratory properties, as well as the possibility to generate human glioma-like upon orthotopic transplantation of 500 cells into the murine brain. The gene discussed is NTRK1; the disease is glioma.