In addition, the overexpression of the Spermatogenesis- and oogenesis-specific basic helix-loop-helix transcription factor1 (Sohlh1), a germ cell specific transcription factor that is essential for spermatogonial differentiation and early folliculogenesis, inhibited the cellular proliferation, migration, and invasion in GBM cell lines, whereas Sohlh1 silencing induced an aggressive cellular behavior [117]. The gene discussed is SOHLH1; the disease is glioblastoma.