In the same way, HOXA13, belonging to the Homeobox (HOX) gene family, promotes glioma progression in part via Wnt- and TGF-β-induced EMT and, similar to LEF1, is a potential diagnostic biomarker for GBM and an independent prognostic factor in high-grade glioma [94]. This evidence concerns the gene TGFB1 and central nervous system cancer.