ITGAM and neoplasm: Intriguingly, as shown by Lin and coworkers in mice vaccinated with shikonin (SK)-treated TCL-loaded DC, HSP70 appeared to further boost tumor-directed immunity by inducing a significant decrease of circulating CD11b+Ly6C+ monocytic and CD11b+Ly6G+ granulocytic myeloid-derived suppressor cells (MDSC) [43].