Analysis of ERα and H3K4me3 ChIP-Seq data of primary tumor tissues from patients responding or not to AI treatment [32] showed higher H3K4me3 signal in AI-resistant than in AI-responder patients (Figure 4b); in particular, in four out of six cases of AI-resistant patients a clear H3K4me3 signal at DSCAM-AS1 promoter and gene locus combines with a low but evident ERα ChIP-Seq signal at both E6 and DSCAM-AS1 promoter (Supplementary Figure S2d). Here, ESR1 is linked to neoplasm.