ANXA2 and Familial prostate cancer: Importantly, increased levels of annexin A2, metalloproteinases, and diverse signalling molecules (TGF-β2, TNF1α, IL6, TSG101, Akt, ILK1, and β-catenin) were detected in exosomes secreted from prostate cancer cells under hypoxic conditions, suggesting that hypoxia-induced exosomes enhance invasiveness, stemness, and induce microenvironment changes, promoting PCA aggressiveness [125].