ANXA2 and Familial prostate cancer: Annexin A2 expression is increased in many cancers, including leukaemias, clear cell renal cell carcinoma, breast, cervical, colorectal, endometrial, gastric cancer, glioblastoma, hepatocellular carcinoma [20], but specifically decreased in prostate cancer [21], which might have a bearing on the regulation of cell motility in different forms of the disease.