TLR7 and cancer: Taking into account the following factors: 1) the similarity between the predicted binding mode of CR42-24 and the R-837 one, which was assessed experimentally, 2) the similarities between the CR42-24 pose in TLR7 and the colchicine pose in tubulin and 3) the negative IC50 shift observed for TLR7-mutated cell lines, we suggest a possible off-target interaction between our colchicine derivative, CR42-24, and the TLR7 dimer, with a possible anti-cancer effect.