FOXP3 and neoplasm: By cloning tumor-infiltrating lymphocytes (TILs) from both marginal and center tumor tissues of surgically resected PDA patients, we clearly obtained a different set of ENO1-specific T cells: most patients displayed a higher number of clones with a Th1/Th17 (IFNγ and/or IL17 producers) phenotype in the marginal tumor area paralleled by a higher number of clones with a T regulatory lymphocytes (Treg) phenotype (FoxP3+ and IL10 producers) [14].