ENO1 and Patent ductus arteriosus: The crucial role of anti-ENO1 antibodies was confirmed by the observation that ENO1 vaccinated mice showed B cells organized in dense aggregates that displayed a distinct structure, the so-called tertiary lymphoid tissue (TLT), which were not found in normal pancreases, and only sporadically in PDA of untreated mice or those vaccinated with an empty-vector [21].