Histone acetylation, as estimated by the expression level of PanH3ac (Histone H3ac pan-acetyl), an estimate of HDACi capacity between high fiber and chow-fed mice, was not affected by fiber treatment (Figure 7B), making HDACi less likely to be involved in the fiber effect in our model, in spite of the fact that high fiber treatment increased the butyrate level, which has been widely accepted as the most potent HDAC inhibitor responsible for the beneficial effects of SCFA in CRC [38,39,40,41,42,43,44,45,46,47,48,49,50,51,52,53,54,55,56,57,58,59,60,61,62,63]. This evidence concerns the gene HDAC9 and colorectal carcinoma.