TGFBR2 and colorectal carcinoma: In the CRC cell line HCT116 expressing the biallelic inactivation of TGFBR2, the reconstitution with a wild type TGFBR2 gene leads to altered sialylation of a variety of glycoproteins [163,164], without any change in the expression of sialyltransferases [164], suggesting a relationship between sialylation and a classical mutational step in CRC.