Ellisen and coworkers were the first to associate Notch with cancer; they reported that in T-cell acute lymphocytic leukemia (T-ALL), Notch1 gets constitutively activated due to chromosomal translocation t(7;9)(q34; q34.3), found in about 1% of T-ALL patients [21]. Here, NOTCH1 is linked to acute lymphoblastic leukemia.