Notably, there is controversy about the role of RBPjk in cancer: in fact, consistent with its transcriptional repressor function, RBPjk depletion can promote tumorigenesis [73,74]; however, RBPjk was also found highly expressed in glioblastomas, and its targeting decreased self-renewal of brain tumor-initiating cell and tumor formation [75]. This evidence concerns the gene RBPJ and brain neoplasm.