Combination of DLL4-blockade by either Dll4-Fc or anti-DLL4 antibodies (REGN1035, REGN421) with VEGF-trap Aflibercept showed stronger efficacy in reducing tumor burden compared to monotherapy, by blocking angiogenesis and eliciting cancer cell apoptosis in murine tumors [118]. This evidence concerns the gene DLL4 and neoplasm.