Alternative splicing of exon 8 of the VEGF-A gene results in the expression of an anti-angiogenic, anti-permeability, and cyto-protective family of isoforms, termed the VEGF-Axxxb family (the most common isoform being VEGF-A165b) [13], which has been shown to be protective in kidney disease [9,10]. The gene discussed is VEGFA; the disease is kidney disorder.