CXCR4 and neoplasm: In addition, platelet and tumor cell-derived MVs could play a vital role in angiogenesis by transferring a series of proangiogenic factors, including growth factors such as vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF) and platelet-derived growth factor (PDGF), chemokine receptors such as C–C chemokine receptor type 5 (CCR5), C-X-C chemokine receptor type 4 (CXCR4), and matrix metalloproteinases (MMPs) such as MMP2 and MMP9, which contribute to vessel repair, sprouting, and invasiveness [36], [37].