In autosomal dominantly inherited Alzheimer’s disease, a successive emergence of abnormal CSF concentrations of amyloid-β, tau, microglial activation, grey matter atrophy and cerebral glucose hypometabolism has been reported (Bateman et al., 2012; Benzinger et al., 2013; Suarez-Calvet et al., 2016). This evidence concerns the gene MAPT and Alzheimer disease.