While the β-catenin transcriptional pathway is induced on cancer cells during the course of tumor progression by protumoral, M2-type tumor-associated macrophages [41, 42], our present study is the first one, to our knowledge, to propose that an EMT-like, β-catenin/TC4-driven tumor phenotype shift is induced by macrophages on tumor cells in the context of acute inflammation. Here, RAN is linked to neoplasm.