We found that the expression of ZEB1, SNAI1 and SNAI2 were clearly induced in the two colon cancer cell lines by MACRO-CM from U937 macrophages, with the exception of HT-29 cells that did not expressed detectable levels of SNAI2 mRNA under any culture condition (Fig 8). The gene discussed is SNAI1; the disease is malignant colon neoplasm.