Summarizing, the inflammatory medium released by differentiated THP-1 or U937 macrophages led to a phenotypic shift in colon cancer cells with features of EMT, including increased cell invasiveness, activation of a gene expression program controlled by β-catenin/TCF4, and induction of mesenchymal markers and transcription factors genes related to the EMT process. This evidence concerns the gene TCF4 and colonic neoplasm.