The integrin subunit beta 6 protein mRNA (ITGB6) was induced in the two colon cancer cell lines by treatment with MACRO-CM from U937 macrophages, and the colon cancer metastasis-related protein S100A4 mRNA was induced in SW620 cells by treatment with THP-1 MACRO-CM (Fig 6). This evidence concerns the gene S100A4 and malignant colon neoplasm.