For 39 patients with confirmed eGFR decline both at the EoT and FU12, the possible association among renal function impairment and other comorbidities (hypertension, diabetes), TDF, PI, INSTI or RBV use, as well as baseline characteristics of the patients (age, sex, duration of HIV and HCV infection, HIV stage, baseline HCV-RNA and platelet count, CD4+ T-cell nadir and BL CD4+T-cell count, liver stiffness and previous HCV treatment) was investigated (Table 2). Here, CD4 is linked to diabetes mellitus.