Given the broad regulatory effects of Lin28/Let-7, and the role of thymic B cells in central tolerance, our findings have potential implications for improving the transplantation of umbilical cord blood cells or adult BM cells, autoimmune disease, and for understanding the contributions of microenvironmental signals in cancer formation due to the disorder of Lin28/Let-7 axis [40]. This evidence concerns the gene LIN28A and autoimmune disease.