In addition, various PDE family members, PDE1A, PDE3A, PDE4B, PDE4D, PDE5 and PDE9A, are implicated in the cardiac stress response, which triggers pathological cardiac remodeling and ultimately cardiac dysfunction (e.g., heart failure and arrhythmias) [34,152,153,154,155,156]. Here, PDE5A is linked to heart failure.