The propensity of some tumor to metastasize to bone depends on many factors such as the expression of adhesive molecules and bone markers on the surface of tumor cells (i.e., vitamin D receptor, RANKL, RUNX2, αVβ3, etc.)[2,3]; the expression of a set of genes associated with bone metastases [4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21]; and the capability of performing the epithelial–mesenchymal transition (EMT) of carcinomas [2,3,22,23,24,25,26,27,28,29,30,31,32,33,34,35,36,37,38,39,40,41,42,43,44,45,46,47,48,49,50,51,52,53,54,55,56,57,58,59,60,61]. This evidence concerns the gene RUNX2 and neoplasm.