SMAD2 and hypertensive disorder: (3) The hypertension-enhanced renal fibrotic pathways were less activated after exercise training, with evidence of attenuates in transforming growth factor-beta (TGF-β), phospho-Smad2/3 (p-Smad2/3), connective tissue growth factor (CTGF), matrix metalloproteinase-9 (MMP-9), and matrix metalloproteinase-2 (MMP-2) after exercise training, when compared with the sedentary hypertension.